A new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by EPR spectroscopy

Eduardo Guimarães Vieira; Rodrigo Boni Fazzi; Daniel O. T. A. Martins; Alena M. Sheveleva; Floriana Tuna; Ana Maria da Costa Ferreira

doi:10.1039/D2RA07266A

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

A new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by EPR spectroscopy†

Eduardo Guimarães Vieira,

^ab Rodrigo Boni Fazzi,^a Daniel O. T. A. Martins,

^b Alena M. Sheveleva,^b Floriana Tuna

*^b and Ana Maria da Costa Ferreira

*^a

Author affiliations

* Corresponding authors

^a Department of Fundamental Chemistry, Institute of Chemistry, University of São Paulo, 05508-000 São Paulo-SP, Brazil
E-mail: amdcferr@iq.usp.br

^b EPSRC National EPR Facility, Department of Chemistry and Photon Science Institute, University of Manchester, Manchester M13 9PL, UK
E-mail: floriana.tuna@manchester.ac.uk

Abstract

A novel strategy of improving cytotoxicity against metastatic melanoma cells using an oxindolimine copper(II) complex immobilized and dimerized on a modified Polyhedral Oligomeric Silsesquioxane (POSS) matrix was developed, as revealed by electron paramagnetic resonance (EPR) spectroscopy. An assured correlation between continuous-wave (CW) and pulsed EPR spectroscopies provided a complete characterization of the actual active species, its coordination environment, as well as the efficiency/selectivity of the bioconjugate materials.

This article is part of the themed collection: Celebrating the 200th Anniversary of the University of Manchester

Download options Please wait...

Supplementary files

Supplementary information PDF (1181K)

Article information

DOI: https://doi.org/10.1039/D2RA07266A
Article type: Paper
Submitted: 15 Nov. 2022
Accepted: 20 Marts 2023
First published: 24 Marts 2023
This article is Open Access

Download Citation

RSC Adv., 2023,13, 9715-9719

Permissions

Request permissions

A new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by EPR spectroscopy

E. G. Vieira, R. B. Fazzi, D. O. T. A. Martins, A. M. Sheveleva, F. Tuna and A. M. da Costa Ferreira, RSC Adv., 2023, 13, 9715 DOI: 10.1039/D2RA07266A

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

RSC Advances

A new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by EPR spectroscopy†

Abstract

Supplementary files

Article information

Download Citation

Permissions

A new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by EPR spectroscopy

Social activity

Search articles by author

Spotlight

Advertisements