Organophotoelectrocatalytic C(sp2)–H alkylation of heteroarenes with unactivated C(sp3)–H compounds

Qinhui Wan; Xia-Die Wu; Zhong-Wei Hou; Yongmin Ma; Lei Wang

doi:10.1039/D4CC01335B

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Organophotoelectrocatalytic C(sp²)–H alkylation of heteroarenes with unactivated C(sp³)–H compounds†

Qinhui Wan,^a Xia-Die Wu,^a Zhong-Wei Hou,*^a Yongmin Ma^a and Lei Wang

*^ab

Author affiliations

* Corresponding authors

^a Advanced Research Institute and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang, P. R. China
E-mail: zhongwei.hou@tzc.edu.cn, leiwang88@hotmail.com

^b College of Material Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou, Zhejiang, P. R. China

Abstract

An organophotoelectrocatalytic method for the C(sp²)–H alkylation of heteroarenes with unactivated C(sp³)–H compounds through dehydrogenation cross-coupling has been developed. The C(sp²)–H alkylation combines organic catalysis, photochemistry and electrochemistry, avoiding the need for external metal-reagents, HAT-reagents, and oxidants. This protocol exhibits good substrate tolerance and functional group compatibility, providing a straightforward and powerful pathway to access a variety of alkylated heteroarenes under green conditions.

This article is part of the themed collection: Electrochemically driven catalytic organic transformations

Download options Please wait...

Supplementary files

Supplementary information PDF (4181K)

Article information

DOI: https://doi.org/10.1039/D4CC01335B
Article type: Communication
Submitted: 23 Marts 2024
Accepted: 25 Apr. 2024
First published: 26 Apr. 2024

Download Citation

Chem. Commun., 2024,60, 5502-5505

Permissions

Request permissions

Organophotoelectrocatalytic C(sp²)–H alkylation of heteroarenes with unactivated C(sp³)–H compounds

Q. Wan, X. Wu, Z. Hou, Y. Ma and L. Wang, Chem. Commun., 2024, 60, 5502 DOI: 10.1039/D4CC01335B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications