Ferroptosis-inducing photosensitizers alleviate hypoxia tumor microenvironment for enhanced fluorescence imaging-guided photodynamic therapy

Linhao Zhang; Maomao He; Xiang Xia; Zhiyuan Ma; Chengyuan Lv; Ran Wang; Wenkai Liu; Jiangli Fan; Xiaojun Peng; Wen Sun

doi:10.1039/D4CC02391A

Ferroptosis-inducing photosensitizers alleviate hypoxia tumor microenvironment for enhanced fluorescence imaging-guided photodynamic therapy†

Linhao Zhang,^a Maomao He,^a Xiang Xia,^a Zhiyuan Ma,^a Chengyuan Lv,^a Ran Wang,^a Wenkai Liu,^a Jiangli Fan,

^ab Xiaojun Peng

^a and Wen Sun

*^ab

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* Corresponding authors

^a State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China
E-mail: sunwen@dlut.edu.cn

^b Ningbo Institute of Dalian University of Technology, Ningbo 315016, China

Abstract

This study describes H₂O₂-activated photosensitizer nanoparticles (ICyHD NPs), which inhibit histone deacetylase via binding Zn²⁺ to induce ferroptosis and upregulate the intracellular O₂, thus resulting in enhanced photodynamic therapeutic effect. ICyHD NPs exert strong antitumor effects on mice and have improved the therapeutic precision via observing the increase in cellular fluorescence.

This article is part of the themed collection: 2024 Pioneering Investigators

Chemical Communications

Ferroptosis-inducing photosensitizers alleviate hypoxia tumor microenvironment for enhanced fluorescence imaging-guided photodynamic therapy†

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Ferroptosis-inducing photosensitizers alleviate hypoxia tumor microenvironment for enhanced fluorescence imaging-guided photodynamic therapy

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