Issue 93, 2024

A giant macrocycle overcomes the post-treatment phototoxicity of photofrin through host–guest complexation

Abstract

Here we reported a supramolecular sequestration strategy to overcome the post-treatment phototoxicity of photofrin via direct host–guest complexation. Efficient recognition potency of a giant pentaphen[3]arene derivative could favor suppressing sunlight-induced skin damage through weakening the ability of complexed photofrin to generate singlet oxygen.

Graphical abstract: A giant macrocycle overcomes the post-treatment phototoxicity of photofrin through host–guest complexation

Supplementary files

Article information

Article type
Communication
Submitted
15 Sept. 2024
Accepted
16 Okt. 2024
First published
25 Okt. 2024

Chem. Commun., 2024,60, 13686-13689

A giant macrocycle overcomes the post-treatment phototoxicity of photofrin through host–guest complexation

S. Lin, X. Yu, Z. Zhang, Y. Zhang, J. Chen, C. Li and Q. Meng, Chem. Commun., 2024, 60, 13686 DOI: 10.1039/D4CC04777J

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