Detecting single-point isomeric differences in polymer chains by MOF column chromatography

Abstract

Liquid chromatography with a metal–organic framework (MOF) as the stationary phase enables nanopore threading-based recognition of polymers and identification of single-point isomeric structural differences in the polymer main chain. The polymer adsorption affinity to the MOF and transient kinetics of polymer insertion into the nanopores play crucial roles in the recognition process.