Analytical developments in the synergism of copper particles and cysteine: a review

Abstract

Cysteine, a sulfur-containing amino acid, is a vital candidate for physiology. Coinage metal particles (both clusters and nanoparticles) are highly interesting for their spectacular plasmonic properties. In this case, copper is the most important candidate for its cost-effectiveness and abundance. However, rapid oxidation destroys the stability of copper particles, warranting the necessity of suitable capping agents and experimental conditions. Cysteine can efficiently carry out such a role. On the contrary, cysteine sensing is a vital step for biomedical science. This review article is based on a comparative account of copper particles with cysteine passivation and copper particles for cysteine sensing. For the deep understanding of readers, we discuss nanoparticles and nanoclusters, properties of cysteine, and importance of capping agents, along with various synthetic protocols and applications (sensing and bioimaging) of cysteine-capped copper particles (cysteine-capped copper nanoparticles and cysteine-capped copper nanoclusters). We also include copper nanoparticles and copper nanoclusters for cysteine sensing. As copper is a plasmonic material, fluorometric and colorimetric methods are mostly used for sensing. Real sample analysis for both copper particles with cysteine and copper particles for cysteine sensing are also incorporated in this review to demonstrate their practical applications. Both cysteine-capped copper particles and copper particles for cysteine sensing are the main essence of this review. The aspect of the synergism of copper and cysteine (unlike other amino acids) is quite promising for future researchers.