Issue 7, 2024

Biocompatible cellulose nanocrystal-based Trojan horse enables targeted delivery of nano-Au radiosensitizers to triple negative breast cancer cells

Abstract

A hybrid cellulose-based programmable nanoplatform for applications in precision radiation oncology is described. Here, sugar heads work as tumor targeting moieties and steer the precise delivery of radiosensitizers, i.e. gold nanoparticles (AuNPs) into triple negative breast cancer (TNBC) cells. This “Trojan horse” approach promotes a specific and massive accumulation of radiosensitizers in TNBC cells, thus avoiding the fast turnover of small-sized AuNPs and the need for high doses of AuNPs for treatment. Application of X-rays resulted in a significant increase of the therapeutic effect while delivering the same dose, showing the possibility to use roughly half dose of X-rays to obtain the same radiotoxicity effect. These data suggest that this hybrid nanoplatform acts as a promising tool for applications in enhancing cancer radiotherapy effects with lower doses of X-rays.

Graphical abstract: Biocompatible cellulose nanocrystal-based Trojan horse enables targeted delivery of nano-Au radiosensitizers to triple negative breast cancer cells

Supplementary files

Article information

Article type
Communication
Submitted
30 Janv. 2024
Accepted
08 Maijs 2024
First published
14 Maijs 2024
This article is Open Access
Creative Commons BY license

Nanoscale Horiz., 2024,9, 1211-1218

Biocompatible cellulose nanocrystal-based Trojan horse enables targeted delivery of nano-Au radiosensitizers to triple negative breast cancer cells

G. Biagiotti, R. Cazzoli, P. Andreozzi, G. Aresta, M. Francesco, C. Mangini, P. di Gianvincenzo, C. Tobia, S. Recchia, L. Polito, M. Severi, O. Vittorio, S. Cicchi, S. E. Moya, R. Ronca, A. Albini, D. Berti, R. Orecchia, C. Garibaldi, S. Minucci and B. Richichi, Nanoscale Horiz., 2024, 9, 1211 DOI: 10.1039/D4NH00042K

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