H2O2-stimulated Janus-shaped self-propelled nanomotors as an active treatment for acute renal injury

Abstract

As emerging nanosystems, nanomotors have been applied in the active treatment of many diseases. In this paper, Pt@chitosan-loaded melatonin asymmetrical nanomaterials embedded with L-serine (S, kidney injury molecule 1-targeting agent) were constructed to alleviate acute kidney injury (AKI). The Janus nanocarriers arrived at the renal injury site via the bloodstream and exhibited high permeability. Because of melatonin distribution in the kidneys combined with H₂O₂-stimulated O₂ release, the administration of the Janus nanosystem resulted in active treatment through the motion of nanomotors by asymmetrical O₂ release.