Foundational insights for theranostic applications of magnetoelectric nanoparticles

Victoria Andre; Mostafa Abdel-Mottaleb; Max Shotbolt; Shawnus Chen; Zeinab Ramezini; Elric Zhang; Skye Conlan; Ozzie Telisman; Ping Liang; John M. Bryant; Roman Chomko; Sakhrat Khizroev

doi:10.1039/D4NH00560K

Foundational insights for theranostic applications of magnetoelectric nanoparticles

Victoria Andre,^a Mostafa Abdel-Mottaleb,^a Max Shotbolt,^a Shawnus Chen,^b Zeinab Ramezini,^c Elric Zhang,^c Skye Conlan,^a Ozzie Telisman,^d Ping Liang,^e John M. Bryant,^f Roman Chomko^g and Sakhrat Khizroev

*^ch

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* Corresponding authors

^a Department of Biomedical Engineering, University of Miami, Coral Gables, FL, USA

^b Department of Chemical, Environmental and Materials Engineering, University of Miami, Coral Gables, FL, USA

^c Department of Electrical and Computer Engineering, University of Miami, Coral Gables, FL, USA
E-mail: skhizroev@miami.edu

^d Department of Chemistry, University of Miami, Coral Gables, FL, USA

^e Cellular Nanomed, Irvine, CA, USA

^f H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

^g Department of Electrical and Computer Engineering, University of California, Riverside, CA, USA

^h The Miami Project to Cure Paralysis, Department of Biochemistry and Molecular Biology, University of Miami, Miami, FL, USA

Abstract

Reviewing emerging biomedical applications of MagnetoElectric NanoParticles (MENPs), this paper presents basic physics considerations to help understand the possibility of future theranostic applications. Currently emerging applications include wireless non-surgical neural modulation and recording, functional brain mapping, high-specificity cell electroporation for targeted cancer therapies, targeted drug delivery, early screening and diagnostics, and others. Using an ab initio analysis, each application is discussed from the perspective of its fundamental limitations. Furthermore, the review identifies the most eminent challenges and offers potential engineering solutions on the pathway to implement each application and combine the therapeutic and diagnostic capabilities of the nanoparticles.

This article is part of the themed collection: Recent Review Articles

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Foundational insights for theranostic applications of magnetoelectric nanoparticles

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