Issue 42, 2010
From the journal:

Chemical Communications

Simultaneous iridium catalysed oxidation and enzymatic reduction employing orthogonal reagents†‡

Francesco G. Mutti,a   Andreas Orthaber,b   Joerg H. Schrittwieser,a   Johannes G. de Vries,c   Rudolf Pietschnigb  and  Wolfgang Kroutil*a  

* Corresponding authors

a Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, Heinrichstrasse 28, A-8010 Graz, Austria
E-mail: Wolfgang.Kroutil@uni-graz.at
Fax: +43 316 380 9840
Tel: +43 316 380 5350

b Department of Chemistry, Inorganic Chemistry, University of Graz, Schubertstrasse 1, A-8010 Graz, Austria

c DSM Innovative Synthesis BV, A unit of DSM Pharma Chemicals, PO Box 18, 6160 MD Geleen, The Netherlands

Abstract

An iridium catalysed oxidation was coupled concurrently to an asymmetric biocatalytic reduction in one-pot; thus it was shown for the first time that iridium- and alcohol dehydrogenase-catalysed redox reactions are compatible. As a model system racemic chlorohydrins were transformed to enantioenriched chlorohydrins via an oxidation–asymmetric reduction sequence.

Graphical abstract: Simultaneous iridium catalysed oxidation and enzymatic reduction employing orthogonal reagents

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Article information

DOI
https://doi.org/10.1039/C0CC02813D
Article type
Communication
Submitted
26 Jūl. 2010
Accepted
07 Sept. 2010
First published
27 Sept. 2010

Chem. Commun., 2010,46, 8046-8048

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Simultaneous iridium catalysed oxidation and enzymatic reduction employing orthogonal reagents

F. G. Mutti, A. Orthaber, J. H. Schrittwieser, J. G. D. Vries, R. Pietschnig and W. Kroutil, Chem. Commun., 2010, 46, 8046 DOI: 10.1039/C0CC02813D

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