Issue 41, 2010
From the journal:

Chemical Communications

Peptidomimetic inhibitors targeting the CCR5-binding site on the human immunodeficiency virus type-1 gp120 glycoprotein complexed to CD4†‡

Markus Seitz,a   Peter Rusert,b   Kerstin Moehle,a   Alexandra Trkolab  and  John A. Robinson*a  

* Corresponding authors

a Department of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich X, Switzerland
E-mail: robinson@oci.uzh.ch

b Institute of Medical Virology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
E-mail: trkola.alexandra@virology.uzh.ch

Abstract

A helical tyrosine-sulfated epitope in CCR5 that is recognized by the human immunodeficiency virus type-1 envelope glycoprotein gp120 in its CD4-induced conformation can be mimicked structurally by a cyclic β-hairpin peptide containing two sulfated tyrosine residues at positions i and i + 2 along one β-strand.

Graphical abstract: Peptidomimetic inhibitors targeting the CCR5-binding site on the human immunodeficiency virus type-1 gp120 glycoprotein complexed to CD4

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Article information

DOI
https://doi.org/10.1039/C0CC02913K
Article type
Communication
Submitted
30 Jūl. 2010
Accepted
16 Aug. 2010
First published
08 Sept. 2010

Chem. Commun., 2010,46, 7754-7756

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Peptidomimetic inhibitors targeting the CCR5-binding site on the human immunodeficiency virus type-1 gp120 glycoprotein complexed to CD4

M. Seitz, P. Rusert, K. Moehle, A. Trkola and J. A. Robinson, Chem. Commun., 2010, 46, 7754 DOI: 10.1039/C0CC02913K

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