Issue 45, 2010
From the journal:

Chemical Communications

MhyADH catalysed Michael addition of water and in situoxidation†

Jianfeng Jin,ab   Philip C. Oskam,a   Sanjib K. Karmee,a   Adrie J. J. Straathofb  and  Ulf Hanefeld*a  

* Corresponding authors

a Gebouw voor Scheikunde, Afdeling Biotechnologie, Technische Universiteit Delft, Julianalaan 136, 2628 BL Delft, The Netherlands
E-mail: u.hanefeld@tudelft.nl
Fax: +31 (0)15-2781415

b Bioseparation Technology, Afdeling Biotechnologie, Technische Universiteit Delft, Julianalaan 67, 2628 BC Delft, The Netherlands
E-mail: A.J.J.Straathof@tudelft.nl

Abstract

The Michael addition of water is a major challenge. Here an enzymatic approach is described. Interestingly, the enzyme (MhyADH) does not only catalyse the Michael addition of water but also the in situ oxidation of the product.

Graphical abstract: MhyADH catalysed Michael addition of water and in situ oxidation

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Article information

DOI
https://doi.org/10.1039/C0CC03229H
Article type
Communication
Submitted
13 Aug. 2010
Accepted
09 Sept. 2010
First published
27 Sept. 2010

Chem. Commun., 2010,46, 8588-8590

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MhyADH catalysed Michael addition of water and in situ oxidation

J. Jin, P. C. Oskam, S. K. Karmee, A. J. J. Straathof and U. Hanefeld, Chem. Commun., 2010, 46, 8588 DOI: 10.1039/C0CC03229H

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