Issue 3, 2011
From the journal:

Chemical Communications

Ribonuclease S redux†‡

Rex W. Watkins,a   Ulrich Arnold§a  and  Ronald T. Raines*ab  

* Corresponding authors

a Department of Biochemistry, University of Wisconsin–Madison, Madison, Wisconsin, USA
E-mail: rtraines@wisc.edu
Fax: +1 608 890 2583
Tel: +1 608 262 8588

b Department of Chemistry, University of Wisconsin–Madison, Madison, Wisconsin, USA

Abstract

The S-peptide and S-protein components of bovine pancreatic ribonuclease form a noncovalent complex with restored ribonucleolytic activity. Although this archetypal protein-fragment complementation system has been the object of historic work in protein chemistry, intrinsic limitations compromise its utility. Modern methods are shown to overcome those limitations and enable new applications.

Graphical abstract: Ribonuclease S redux

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Article information

DOI
https://doi.org/10.1039/C0CC03864D
Article type
Communication
Submitted
14 Sept. 2010
Accepted
05 Okt. 2010
First published
16 Nov. 2010

Chem. Commun., 2011,47, 973-975

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Ribonuclease S redux

R. W. Watkins, U. Arnold and R. T. Raines, Chem. Commun., 2011, 47, 973 DOI: 10.1039/C0CC03864D

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