Asymmetric hydrogenation of alkenes lacking coordinating groups

Abstract

Asymmetric hydrogenation of olefins is one of the most important reactions for the synthesis of optically active compounds, especially in industry. Chiral iridium catalysts based on P,N ligands have strongly expanded their application range. In contrast to rhodium and ruthenium diphosphine complexes they do not require the presence of a coordinating group near the CC bond and, therefore, allow highly enantioselective hydrogenations of largely unfunctionalized alkenes.