A strategy for enhanced antibacterial activity against Staphylococcus aureus by the assembly of alamethicin with a thermo-sensitive polymeric carrier

Abstract

We demonstrate here a strategy for enhanced antibacterial activity against microbial strains by the assembly of antimicrobial peptides with a temperature-responsive polymeric carrier. The assembly complex was less toxic to human cells and more stable to enzymatic cleavage. This work may provide a promising drug delivery system for antimicrobial peptides.