Combating pathogens with Cs2.5H0.5PW12O40 nanoparticles: a new proton-regulated antimicrobial agent

Roger Honorato Piva; Marina Campos Rocha; Diógenes Honorato Piva; Oscar Rubem Klegues Montedo; Hidetake Imasato; Iran Malavazi; Ubirajara Pereira Rodrigues-Filho

doi:10.1039/C7TB02763J

Combating pathogens with Cs_2.5H_0.5PW₁₂O₄₀ nanoparticles: a new proton-regulated antimicrobial agent†

Roger Honorato Piva,

‡*^a Marina Campos Rocha,‡^b Diógenes Honorato Piva,

^c Oscar Rubem Klegues Montedo,

^d Hidetake Imasato,^a Iran Malavazi^b and Ubirajara Pereira Rodrigues-Filho^a

Author affiliations

* Corresponding authors

^a Grupo de Química de Materiais Híbridos e Inorgânicos, Instituto de Química de São Carlos, Universidade de São Paulo, São Carlos – SP, Brazil
E-mail: honorato.piva@ua.pt

^b Departamento de Genética e Evolução, Centro de Ciências Biológicas e da Saúde, Universidade Federal de São Carlos, São Carlos – SP, Brazil

^c Programa de Pós-Graduação em Ciência e Engenharia de Materiais – PPG-CEM, Universidade Federal de São Carlos, São Carlos – SP, Brazil

^d Grupo de Pesquisa em Cerâmica Técnica – CERTEC, Programa de Pós-Graduação em Ciência e Engenharia de Materiais – PPGCEM, Universidade do Extremo Sul Catarinense, Criciúma – SC, Brazil

Abstract

The transfer of pathogens from contaminated surfaces to patients is one of the main causes of health care-associated infections (HCAIs). Cases of HCAIs due to multidrug-resistant organisms have been growing worldwide, whereas inorganic nano-antimicrobials are valuable today for the prevention and control of HCAIs. Here, we present a cesium salt of phosphotungstic heteropolyacid (Cs_2.5H_0.5PW₁₂O₄₀) as a promising nanomaterial for use in antimicrobial product technologies. This water-insoluble Keggin salt exhibits a broad biocide spectrum against Gram-positive and Gram-negative bacteria, yeasts, and filamentous fungi even under dark conditions. The Cs_2.5H_0.5PW₁₂O₄₀ nanoparticles (NPs) act as a proton-regulated antimicrobial whose activity is mediated on the release of hydronium ions (H₃O⁺), yielding an in situ acidic pH several units below those tolerable by most of the fungal and bacterial nosocomial pathogens.

This article is part of the themed collection: Materials and Nano Research in Brazil

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Article information

DOI: https://doi.org/10.1039/C7TB02763J
Article type: Paper
Submitted: 20 Okt. 2017
Accepted: 01 Dec. 2017
First published: 01 Dec. 2017

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J. Mater. Chem. B, 2018,6, 143-152

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Combating pathogens with Cs_2.5H_0.5PW₁₂O₄₀ nanoparticles: a new proton-regulated antimicrobial agent

R. H. Piva, M. C. Rocha, D. H. Piva, O. R. K. Montedo, H. Imasato, I. Malavazi and U. P. Rodrigues-Filho, J. Mater. Chem. B, 2018, 6, 143 DOI: 10.1039/C7TB02763J

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Journal of Materials Chemistry B