Approaches for the isolation and identification of hydrophilic, light-sensitive, volatile and minor natural products
Abstract
Covering: up to 2019
The discovery of new bioactive natural products gained momentum during the last few decades, resulting from instrumentation advances, from the expansion of genome mining and regulation, as well as by exploration of untapped biological sources. However, water-soluble, volatile, minor and photosensitive natural products are yet poorly known. This review discusses the literature reporting the isolation strategies for some of these metabolites. Analysis of minor metabolites at sub-milligram level are also presented, since analytical instrumentation enabling structure assignment in minute quantities is now routine. Major trends related to natural products discovery are discussed, under the light of further developments in biodiscovery.
- This article is part of the themed collections: Celebrating Latin American Talent in Chemistry and New methods for isolation and structure determination of natural products
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