Hyaluronic acid functionalized gold nanorods combined with copper-based therapeutic agents for chemo-photothermal cancer therapy

Lina Gao; Lei Zhang; Xuyu Zhu; Jing Chen; Meng Zhao; Simin Li; Chengli Yu; Lihong Hu; Hongzhi Qiao; Zijian Guo

doi:10.1039/D0TB00097C

Hyaluronic acid functionalized gold nanorods combined with copper-based therapeutic agents for chemo-photothermal cancer therapy†

Lina Gao,

‡^a Lei Zhang,‡^a Xuyu Zhu,^a Jing Chen,^b Meng Zhao,^a Simin Li,^a Chengli Yu,^a Lihong Hu,*^a Hongzhi Qiao

*^abc and Zijian Guo

^c

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* Corresponding authors

^a Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China
E-mail: qiaohz@njucm.edu.cn, lhhu@njucm.edu.cn

^b Jiangsu Engineering Research Center for Efficient Delivery System of TCM, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China

^c State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China

Abstract

We herein report a hybrid nanocomposite (AuNRs-CTN@THA) which is based on hyaluronic acid-coated gold nanorods with loading of a copper complex through strong bonds. AuNRs-CTN@THA exhibits durable photothermal conversion capacity for pH-dominant and pH/temperature dual sensitive drug release, accomplishing synergetic antitumor efficacy and deep tumor penetration.

This article is part of the themed collection: Hybrid Nanoparticle Composites

Journal of Materials Chemistry B

Hyaluronic acid functionalized gold nanorods combined with copper-based therapeutic agents for chemo-photothermal cancer therapy†

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Hyaluronic acid functionalized gold nanorods combined with copper-based therapeutic agents for chemo-photothermal cancer therapy

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