A dual-channel Hill-type small-molecule pH probe

Fang Hu; Yunxia Huang; Yansheng Xiao; Yanchun Li; Xiao Luo; Xuhong Qian; Youjun Yang

doi:10.1039/D1AY00868D

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A dual-channel Hill-type small-molecule pH probe†

Fang Hu,^a Yunxia Huang,^a Yansheng Xiao,^a Yanchun Li,^a Xiao Luo,*^b Xuhong Qian^a and Youjun Yang

*^a

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* Corresponding authors

^a State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, East China University of Science and Technology, Shanghai, China
E-mail: youjunyang@ecust.edu.cn

^b School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China
E-mail: xluo@chem.ecnu.edu.cn

Abstract

By combining a Hill-type pH probe and a pH-insensitive naphthalimide fluorophore, we synthesized a FRET-based ratiometric pH probe (PHHF), exhibiting a reduced pH transition width, representing a unique approach for development of sensitive probes for detection of biorelevant pH changes.

This article is part of the themed collection: Analytical Methods HOT Articles 2021

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Article information

DOI: https://doi.org/10.1039/D1AY00868D
Article type: Communication
Submitted: 23 Maijs 2021
Accepted: 16 Jūn. 2021
First published: 16 Jūn. 2021

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Anal. Methods, 2021,13, 3012-3016

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A dual-channel Hill-type small-molecule pH probe

F. Hu, Y. Huang, Y. Xiao, Y. Li, X. Luo, X. Qian and Y. Yang, Anal. Methods, 2021, 13, 3012 DOI: 10.1039/D1AY00868D

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Analytical Methods

A dual-channel Hill-type small-molecule pH probe†

Abstract

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A dual-channel Hill-type small-molecule pH probe

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