Metabolic iron detection through divalent metal transporter 1 and ferroportin mediated cocktail fluorogenic probes

Yu-Qiang Zhao; Jiahong Duan; Le Yu; Ilwha Kim; Yumin Wang; Yi-Cheng Ma; Cheng-Gang Zou; Ying Zhou; Jun Feng Zhang; Jong Seung Kim

doi:10.1039/D1CC03150C

Metabolic iron detection through divalent metal transporter 1 and ferroportin mediated cocktail fluorogenic probes†

Yu-Qiang Zhao,‡^a Jiahong Duan,‡^b Le Yu,‡^ac Ilwha Kim,^c Yumin Wang,^d Yi-Cheng Ma,^b Cheng-Gang Zou,^b Ying Zhou,*^a Jun Feng Zhang*^d and Jong Seung Kim

*^c

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* Corresponding authors

^a College of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China
E-mail: yingzhou@ynu.edu.cn

^b State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, Yunnan 650091, China

^c Department of Chemistry, Korea University, Seoul 02841, Korea
E-mail: jongskim@korea.ac.kr

^d College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, P. R. China
E-mail: junfengzhang78@126.com

Abstract

A cocktail [1 + 2] dual-fluorescent probe system was developed to realize the real-time visualization of dynamic iron state changes between Fe²⁺ and Fe³⁺ at the cellular level and in multicellular organisms, providing insights into the effect of DMT1 and ferroportin on iron regulation.

This article is part of the themed collections: Multimolecular Crowding in Biosystems and Chemical Communications HOT articles

Chemical Communications

Metabolic iron detection through divalent metal transporter 1 and ferroportin mediated cocktail fluorogenic probes†

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Metabolic iron detection through divalent metal transporter 1 and ferroportin mediated cocktail fluorogenic probes

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