Co(iii)-catalysed regioselective linear C(8)–H olefination of isoquinolone with terminal aromatic and aliphatic alkynes†
Devesh
Chandra, 
‡ab
Nikunj
Kumar,
‡c
Sumit,
ab
Diksha
Parmar,
ab
Puneet
Gupta
*c
and
Upendra
Sharma
*ab
‡ab
Nikunj
Kumar,
‡c
Sumit,
ab
Diksha
Parmar,
ab
Puneet
Gupta
*c
and
Upendra
Sharma
*ab
Abstract
A regioselective C8 linear olefination of isoquinoline-1H-2-one with terminal (aromatic and aliphatic) alkynes is reported under Co(III) catalysis. This is an exclusive report on the C8 functionalization of isoquinolone using non-noble transition metal complexes. Experimental and computational mechanistic studies have also been performed to depict the reaction pathway.
- This article is part of the themed collection: Functionalization of unreactive C-H bonds
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