Calix[n]triazolium based turn-on fluorescent sensing ensemble for selective adenosine monophosphate (AMP) detection

Jihee Cho; Jinwoo Shin; Minjung Kang; Peter Verwilst; Changhyun Lim; Hanbin Yoo; Jeung Gon Kim; Xingcai Zhang; Chang Seop Hong; Jong Seung Kim; Sanghee Kim

doi:10.1039/D1CC04950J

Calix[n]triazolium based turn-on fluorescent sensing ensemble for selective adenosine monophosphate (AMP) detection†

Jihee Cho,

‡^a Jinwoo Shin,

‡^b Minjung Kang,‡^b Peter Verwilst,

^c Changhyun Lim,

^a Hanbin Yoo,

^a Jeung Gon Kim,

^d Xingcai Zhang,

^ef Chang Seop Hong,

*^b Jong Seung Kim

*^b and Sanghee Kim

*^a

Author affiliations

* Corresponding authors

^a College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea
E-mail: pennkim@snu.ac.kr

^b Department of Chemistry, Korea University, Seoul 02841, Korea
E-mail: blackhock10@naver.com, jongskim@korea.ac.kr

^c KU Leuven, Rega Institute for Medical Research, Medicinal Chemistry, Leuven 3000, Belgium

^d Department of Chemistry and Research Institute of Physics and Chemistry, Jeonbuk National University, Jeonju 54896, Korea

^e John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA

^f School of Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA

Abstract

A novel calix[n]triazolium was synthesized and exhibited excellent selectivity for AMP. The binding between calix[n]triazolium and chromenolate anions forms a non-fluorescent complex and the resulting supramolecular ensemble selectively detects AMP in water and induces “turn-on” fluorescence. The sensing platform is the first macrocyclic system to discriminate AMP from ADP and ATP through fluorescence changes.

This article is part of the themed collection: Multimolecular Crowding in Biosystems

Chemical Communications

Calix[n]triazolium based turn-on fluorescent sensing ensemble for selective adenosine monophosphate (AMP) detection†

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Calix[n]triazolium based turn-on fluorescent sensing ensemble for selective adenosine monophosphate (AMP) detection

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