Surface presentation of the noncanonical Wnt5a motif to cytotoxic CD8+ T-cells promotes their mechanotransduction and activation

Rui Li; Walida Ali; Chao Ma; Apratim Bajpai; Ngoc Luu; Aarushi Varshney; Camden Riley Rowe; Weiqiang Chen

doi:10.1039/D1CC05194F

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Surface presentation of the noncanonical Wnt5a motif to cytotoxic CD8⁺ T-cells promotes their mechanotransduction and activation†

Rui Li,

^ab Walida Ali,

^a Chao Ma,

^ab Apratim Bajpai,^b Ngoc Luu,^a Aarushi Varshney,^a Camden Riley Rowe

^a and Weiqiang Chen

*^abc

Author affiliations

* Corresponding authors

^a Department of Biomedical Engineering, New York University, New York, USA
E-mail: wchen@nyu.edu

^b Department of Mechanical and Aerospace Engineering, New York University, New York, USA

^c Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, USA

Abstract

We report here strategic functionalization of the Wnt5a mimetic peptide ligand Foxy5 on a polydimethylsiloxane elastomer substrate to enhance the mechanotransduction and activation of cytotoxic CD8⁺ T cells by triggering the noncanonical Wnt signaling. This new mechanoregulatory ligand platform can be widely applied in the fundamental research of mechano-immunology and further the development of novel immunotherapies.

This article is part of the themed collection: 2021 Emerging Investigators

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Article information

DOI: https://doi.org/10.1039/D1CC05194F
Article type: Communication
Submitted: 14 Sept. 2021
Accepted: 04 Nov. 2021
First published: 04 Nov. 2021

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Chem. Commun., 2021,57, 12667-12670

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Surface presentation of the noncanonical Wnt5a motif to cytotoxic CD8⁺ T-cells promotes their mechanotransduction and activation

R. Li, W. Ali, C. Ma, A. Bajpai, N. Luu, A. Varshney, C. R. Rowe and W. Chen, Chem. Commun., 2021, 57, 12667 DOI: 10.1039/D1CC05194F

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Chemical Communications