Coordination effect enabled palladium-catalyzed regioselective O-alkylation of 2-pyridones

Zhiqiang Lu; Yanzhi Li; Yi Ru; Shujian Yang; Chu Hao; Mengke Zuo; Rongkai Jiao; Weilong Wu; Yan Zhou; Hui Yao; Nianyu Huang; Yuqin Fu

doi:10.1039/D1CC06110K

Coordination effect enabled palladium-catalyzed regioselective O-alkylation of 2-pyridones†

Zhiqiang Lu,

*^ab Yanzhi Li,^ab Yi Ru,^a Shujian Yang,^a Chu Hao,^a Mengke Zuo,^a Rongkai Jiao,^a Weilong Wu,^a Yan Zhou,^a Hui Yao,

*^b Nianyu Huang*^b and Yuqin Fu*^a

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* Corresponding authors

^a College of Chemistry and Chemical Engineering and Henan Key Laboratory of Function-Oriented Porous Materials, Luoyang Normal University, Luoyang, P. R. China
E-mail: zqlu2000@lynh.edu.cn, lyfuyuqin@126.com

^b Hubei Key Laboratory of Natural Products Research and Development, Key Laboratory of Functional Yeast (China National Light Industry), College of Biological and Pharmaceutical Sciences, Yichang, China Three Gorges University, P. R. China
E-mail: huangny@ctgu.edu.cn, yaohui@ctgu.edu.cn

Abstract

A novel tactic for the regioselective O-alkylation of 2-pyridones has been realized through palladium catalysis in moderate to high yields. The coordination effect between palladium and nitrogen on the pyridine ring plays a versatile role.

This article is part of the themed collection: ChemComm Milestones – First Independent Articles

Chemical Communications

Coordination effect enabled palladium-catalyzed regioselective O-alkylation of 2-pyridones†

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Coordination effect enabled palladium-catalyzed regioselective O-alkylation of 2-pyridones

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