tert-Butyl nitrite triggered radical cascade reaction for synthesizing isoxazoles by a one-pot multicomponent strategy

Abstract

A metal-free radical cyclization/dehydrogenation cascade of alkenes with aldehydes has been developed for the synthesis of 3,5-disubstituted isoxazoles in a one-pot system. This protocol features excellent functional group tolerance and operational simplicity, and is easily scaled up. The radical process is well supported by TEMPO-adducts and the intermediate β-carbonyl ketoxime.