Phosphine-mediated three-component bioconjugation of amino- and azidosaccharides in ionic liquids†
Yvonne D.
Hall, 
‡a
Chiamaka P.
Uzoewulu,
‡a
Zeinab M.
Nizam,
a
Seiya
Ishizawa,
a
Hisham M.
El-Shaffey
a
and
Jun
Ohata
*a
‡a
Chiamaka P.
Uzoewulu,
‡a
Zeinab M.
Nizam,
a
Seiya
Ishizawa,
a
Hisham M.
El-Shaffey
a
and
Jun
Ohata
*a
Abstract
Bioconjugation of carbohydrates has been a challenging task because of their chemical, functional, and structural diversities, and no single chemical modification tool can be universally applicable to all the target substrates in different environments. In this report, we have developed a bioconjugation strategy for labeling of carbohydrate derivatives through a phosphine-mediated three-component coupling reaction in an ionic liquid medium.
- This article is part of the themed collection: 2022 Emerging Investigators
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