A near-infrared GPX4 fluorescent probe for non-small cell lung cancer imaging

Qiao Hu; Wanjie Zhu; Jianjun Du; Saran Long; Wen Sun; Jiangli Fan; Xiaojun Peng

doi:10.1039/D2CC06161A

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A near-infrared GPX4 fluorescent probe for non-small cell lung cancer imaging†

Qiao Hu,^a Wanjie Zhu,^a Jianjun Du,

*^ab Saran Long,^ab Wen Sun,

^ab Jiangli Fan

^ab and Xiaojun Peng

Author affiliations

* Corresponding authors

^a State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, Dalian 116024, China
E-mail: dujj@dlut.edu.cn

^b Ningbo Institute of Dalian University of Technology, 26 Yucai Road, Jiangbei District, Ningbo 315016, China

Abstract

Glutathione peroxidase 4 (GPX4) is overexpressed in non-small cell lung cancer (H1299) cells. In this work, a near-infrared fluorescent probe ENBO-ML210 was developed. In vitro and in vivo imaging results showed that ENBO-ML210 could target and visualize GPX4 in H1299 cells, exhibiting potential for the diagnosis of non-small lung cancer.

This article is part of the themed collections: Chemical Communications HOT Articles 2023 and Chemosensors and Molecular Logic

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Article information

DOI: https://doi.org/10.1039/D2CC06161A
Article type: Communication
Submitted: 14 Nov. 2022
Accepted: 01 Dec. 2022
First published: 02 Dec. 2022

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Chem. Commun., 2023,59, 294-297

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A near-infrared GPX4 fluorescent probe for non-small cell lung cancer imaging

Q. Hu, W. Zhu, J. Du, S. Long, W. Sun, J. Fan and X. Peng, Chem. Commun., 2023, 59, 294 DOI: 10.1039/D2CC06161A

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Chemical Communications

A near-infrared GPX4 fluorescent probe for non-small cell lung cancer imaging†

Abstract

Supplementary files

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A near-infrared GPX4 fluorescent probe for non-small cell lung cancer imaging

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