Mitochondria-targeted fluorophores for in vivo NIR-II imaging-guided PDT/PTT

Qihang Ding; Ling Mei; Yu Liu; Shan Zhou; Lu Chen; Yuying Liang; Mingle Li; Hui Zhou; Chao Yin; Jong Seung Kim

doi:10.1039/D3CC02380J

Mitochondria-targeted fluorophores for in vivo NIR-II imaging-guided PDT/PTT†

Qihang Ding,‡^a Ling Mei,‡^c Yu Liu,‡^b Shan Zhou,^b Lu Chen,^b Yuying Liang,^b Mingle Li,

^a Hui Zhou,

*^b Chao Yin

*^b and Jong Seung Kim

*^a

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* Corresponding authors

^a Department of Chemistry, Korea University, Seoul 02841, Korea
E-mail: jongskim@korea.ac.kr

^b State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China
E-mail: iamhzhou@njupt.edu.cn, iamcyin@njupt.edu.cn

^c Engineering Research Center for Pharmaceuticals and Equipment of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu 610106, China

Abstract

A simple yet powerful D–A type-based NIR-II fluorophore (MTF) with mitochondria targeting was constructed. This mitochondrial targeting dye MTF exhibited not only a photothermal effect but also photodynamic performance, and was further fabricated with DSPE-mPEG to generate nanodots for in vivo experiments, achieving strong NIR-II fluorescence tracing of tumors and impressive NIR-II image-guided photodynamic therapy (PDT) and photothermal therapy (PTT).

This article is part of the themed collection: Chemosensors and Molecular Logic

Chemical Communications

Mitochondria-targeted fluorophores for in vivo NIR-II imaging-guided PDT/PTT†

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Mitochondria-targeted fluorophores for in vivo NIR-II imaging-guided PDT/PTT

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