A water-soluble Gd(iii)-based fluorescence/T1-MR dual-modality probe for H2S sensing

Abstract

We present a water-soluble fluorescence/MR dual-modality probe NBD[Gd] for H₂S detection. It showed 88.4% of fluorescence quenching and a 36% reduction in r₁ upon exposure to H₂S. It is readily uptaken by cells to sense the endogenous H₂S. Besides providing a bimodal H₂S imaging probe, our study also confirms the high H₂S level in CT26 cells and its functional consequence in promoting cell growth.