An overview of molecular biology and nanotechnology based analytical methods for the detection of SARS-CoV-2: promising biotools for the rapid diagnosis of COVID-19
Molecular biology and nanotechnology based analytical methods have proven to be promising diagnostic tools for the rapid diagnosis of COVID-19.
A review of pharmaceutical occurrence and pathways in the aquatic environment in the context of a changing climate and the COVID-19 pandemic
Active pharmaceutical ingredients (APIs) are increasingly being identified as contaminants of emerging concern (CECs).
Critical Review
Current advances in the detection of COVID-19 and evaluation of the humoral response
SARS-CoV-2 and humoral response determinations to understand and control the spread of COVID-19.
Critical Review
Detection of RNA viruses from influenza and HIV to Ebola and SARS-CoV-2: a review
RNA-based viruses likely make up the highest pandemic threat among all known pathogens in about the last 100 years, since the Spanish Flu of 1918 with 50 M deaths up to COVID-19.
Detection of the SARS-CoV-2 spike protein in saliva with Shrinky-Dink© electrodes
We introduce a simple, scalable, and portable electrochemical aptamer-based system for detection of the SARS-CoV-2 spike protein in saliva with attomolar sensitivity.
Colorimetric loop-mediated isothermal amplification (LAMP) for cost-effective and quantitative detection of SARS-CoV-2: the change in color in LAMP-based assays quantitatively correlates with viral copy number
Colorimetric LAMP for COVID-19 intensified diagnostics: a simple and quantitative method comparable in diagnostic performance to RT-qPCR.
Inhibitory activities of marine sulfated polysaccharides against SARS-CoV-2
Sulfated polysaccharide from sea cucumber (SCSP), fucoidan from brown algae, and iota-carrageenan from red algae show inhibitory activities against SARS-CoV-2.
Paper spray mass spectrometry utilizing Teslin® substrate for rapid detection of lipid metabolite changes during COVID-19 infection
Development of an identification methodology with PS-MS as a sensitive and rapid technique to obtain vastly different chemical changes in COVID-19 infection.
Paper
Sample-to-answer COVID-19 nucleic acid testing using a low-cost centrifugal microfluidic platform with bead-based signal enhancement and smartphone read-out
LAMP-based platform for SARS-CoV-2 RNA detection incorporating beads to remove primer-dimers, enhance fluorescent signal and stop the reaction after amplification.
Autonomous lab-on-paper for multiplexed, CRISPR-based diagnostics of SARS-CoV-2
Autonomous lab-on-paper platform for simple, rapid, low-cost, and multiplex gene diagnosis of SARS-CoV-2 in clinical samples.
A graphene oxide coated tapered microfiber acting as a super-sensor for rapid detection of SARS-CoV-2
COVID-19 is a new strain of highly contagious coronavirus. Now, an innovative approach to detect it by combining DNA/RNA oligomers as aptamers and a GO coated optical microfiber as a sensor system.
Thin-film-transistor digital microfluidics for high value in vitro diagnostics at the point of need
The latest developments in thin-film-transistor digital-microfluidics (TFT-DMF) are reported, and proof of concept application to molecular diagnostics (e.g. for coronavirus disease, COVID-19) at the point-of-need demonstrated.
Rapid molecular diagnostics of COVID-19 by RT-LAMP in a centrifugal polystyrene-toner based microdevice with end-point visual detection
We developed a low-cost molecular test for the diagnosis of COVID-19, in a centrifugal microdevice, based on RT-LAMP assay run at 72 °C for 10 min.
A digital protein microarray for COVID-19 cytokine storm monitoring
A digital microfluidic immunoassay platform enables rapid multiplex quantification of proinflammatory cytokines in serum for critically ill COVID-19 patients.
Colorimetric reverse transcription loop-mediated isothermal amplification (RT-LAMP) as a visual diagnostic platform for the detection of the emerging coronavirus SARS-CoV-2
RT-LAMP to detect SARS-CoV-2: in a positive sample, RT-LAMP leads to a color change from pink to yellow.
A high-throughput multiplexed microfluidic device for COVID-19 serology assays
A microfluidic device to quantitate antibody reactivities to SARS-CoV-2 antigens: spike protein, RDB, S1 subunit, and nucleocapsid, from 50 serum samples.
Detection of the SARS-CoV-2 humanized antibody with paper-based ELISA
This work reports the development of a rapid, simple and inexpensive colorimetric paper-based assay for the detection of the severe acute respiratory symptom coronavirus 2 (SARS-CoV-2) humanized antibody.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
COVID-19 is a widespread and highly contagious disease in the human population.
Paper
A modular microarray imaging system for highly specific COVID-19 antibody testing
The TinyArray imager, a robust inexpensive portable imaging device, can detect antibodies against SARS-CoV-2 based on coronavirus antigen microarrays.
Paper
Real-world evaluation of a novel technology for quantitative simultaneous antibody detection against multiple SARS-CoV-2 antigens in a cohort of patients presenting with COVID-19 syndrome
An evaluation of a rapid portable gold-nanotechnology measuring SARS-CoV-2 IgM, IgA and IgG antibody response to spike 1 (S1), spike 2 (S) and nucleocapsid (N) antigens using serum from 74 RNA(+) patients and RNA(+) 47 control patients.
Development of a lateral flow immunoassay strip for rapid detection of IgG antibody against SARS-CoV-2 virus
Rapid and simple LFIA strips based on Au NPs provide a preliminary test result for physicians to make the correct diagnosis of SARS-CoV-2 infections along with alternative testing methods.
In silico evaluation of marine fish proteins as nutritional supplements for COVID-19 patients
To date, no specific drug has been discovered for the treatment of COVID-19 and hence, patients are in a state of anxiety.
Paper
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
The COVID-19 Severity Score combines multiplex biomarker measurements and risk factors in a statistical learning algorithm to predict mortality.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
A 30-minute nucleic acid test for equine respiratory virus from nasal swab material, detected with a smartphone.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
The polymerase chain reaction (PCR) has unique advantages of sensitivity, specificity and rapidity in pathogen detection, which makes it at the forefront of academia and application in molecular biology diagnosis.
Semi-automatic instrumentation for nucleic acid extraction and purification to quantify pathogens on surfaces
A semi-automated detection system compatible with PCR that can detect infectious pathogens on wide surfaces in a short time.
About this collection
All articles on coronavirus research published in the Royal Society of Chemistry Analytical Chemistry Journals can be found here, and are freely available to read until 31st December 2021.