Critical Review
Periodontal disease and emerging point-of-care technologies for its diagnosis
Schematic representation of established biomarkers and various methods developed for diagnosing PD. Created with https://www.BioRender.com.
Rapid miRNA detection in skin interstitial fluid using a hydrogel microneedle patch integrated with DNA probes and graphene oxide
A simple and rapid fluorescence-based sensor sensors using DNA functionalized graphene oxide for miRNA detection from skin interstitial fluid.
Paper
Optimized microfluidic formulation and organic excipients for improved lipid nanoparticle mediated genome editing
Our work elucidates the importance of LNP formulation parameters, including microfluidic flow rate and organic excipient identity, for in vivo gene editing and presents an optimized delivery platform for the treatment of metabolic liver disease.
Paper
Reversibly-bonded microfluidic devices for stable cell culture and rapid, gentle cell extraction
This reversible bonding approach allows for rapid and gentle live cell extraction after long-term on-chip culturing, facilitating downstream manipulation and characterization, and opening new avenues for various applications.
Paper
Dynamic measurement of airway surface liquid volume with an ex vivo trachea-chip
An “ex vivo trachea chip” integrates a tissue explant with a micromachined device, enables dynamic measurements of airway surface liquid volume, and reveals physiology of airway surface liquid secretion and absorption.
OMEF biochip for evaluating red blood cell deformability using dielectrophoresis as a diagnostic tool for type 2 diabetes mellitus
OMEF biochip is open-micro-electro-fluidic technology for stretching of single red blood cells (RBCs) based on dielectrophoresis and electrodeformation. The biochip assesses RBCs' deformability in type 2 diabetes mellitus as an effective diagnostic tool.
On the compatibility of single-cell microcarriers (nanovials) with microfluidic impedance cytometry
We investigate for the first time the compatibility of nanovials with microfluidic impedance cytometry, paving the way for the successful combination of these single-cell technologies.
Paper
Droplet microfluidic system for high throughput and passive selection of bacteria producing biosurfactants
Novel microfluidic technique for functional selection of biosurfactant-producing microorganisms. Single bacterial cells are encapsulated into picoliter droplets for clonal cultivation and passively sorted at high throughput by interfacial tension.
Paper
AMF-SporeChip provides new insights into arbuscular mycorrhizal fungal asymbiotic hyphal growth dynamics at the cellular level
A new microfluidic platform – the AMF-SporeChip – enables immobilisation of arbuscular mycorrhizal fungal spores and confrontation of asymbiotic hyphae with physical obstacles, allowing the identification of various exploration strategies.
A microfluidic chip for sustained oxygen gradient formation in the intestine ex vivo
Here, we have developed a 3D printed microfluidic device capable of oxygen gradient formation within intestinal tissue slices ex vivo. The device is open-welled and compatible with external electrochemical recording during tissue analysis.
Enhanced acoustic streaming effects via sharp-edged 3D microstructures
The use of 3D sharp-edged microstructures enhances the versatility of sharp-edge driven microstreaming, with control over the magnitude and orientation of streaming vortexes for targeted particle microfluidic manipulation.
Quantitative mechanical stimulation of GPR68 using a novel 96 well flow plugin
Mechanosensitive proteins play a crucial role in a range of physiological processes, including hearing and regulating blood flow. This work presents a novel microfluidic approach compatible with 96-well plates to quantify their mechanosensitivity.
Paper
Cascaded elasto-inertial separation of malignant tumor cells from untreated malignant pleural and peritoneal effusions
A cascaded elasto-inertial cell separation device for pretreatment-free, high-recovery-ratio, and high-purity separation of malignant tumor cells from clinical malignant pleural and peritoneal effusions.
A hybrid fluorescent nanofiber membrane integrated with microfluidic chips towards lung-on-a-chip applications
Here, we report a fluorescent electrospun nanofiber membrane for integration with microfluidic chips towards lung-on-a-chip applications complemented with computational fluid dynamics modelling. Created with https://BioRender.com.
Micropillar enhanced FRET-CRISPR biosensor for nucleic acid detection
High-aspect ratio micropillar arrays are fabricated to enhance the detection performance of FRET-CRISPR assay.
About this collection
Lab on a Chip is running a new Emerging Investigator Series to showcase some of the best work in the field of miniaturisation at the micro- and nano-scale, being conducted by exceptional up-and-coming researchers across the microfluidics and miniaturisation community. With this new Emerging Investigator Series, we want to celebrate the major up-and-coming players across this field.
This collection is led by recognised Thought Leaders in the field - David Issadore (University of Pennsylvania) and Sindy Tang (Stanford).