Themed collection Molecular Bioengineering.

Designing short antimicrobial peptides and tuning their interaction with bacterial barriers.

Complex multilayered tissues have been regenerated by extrusion-based 3D bioprinting with biocompatible polymers. Multilayer fabrications with tissue-specific bioinks are possible by controlling gel properties including interaction between layers.

Antibiotics are the main strategy to treat bacterial infections, but can cause bacterial resistance. We comprehensively summarize work on the fabrication of photothermal antibacterial platforms for bacterial infectious skin wound healing.

Schematic depicting enzyme kinetic enhancement when displayed on a nanoparticle surface. We provide a state of the art review of this phenomenon describing what is known about how it arises along with examples grouped by nanomaterials.

Dually-labelled polymeric micelles allowed tracing both the probe location and the levels of singlet oxygen (¹O₂) in biological systems.

Peptides are naturally potent and selective therapeutics with massive potential; however, low cell membrane permeability limits their clinical implementation, particularly for hydrophilic, anionic peptides with intracellular targets.

New diol chemistries are explored for insulin delivery from glucose-responsive hydrogels comprised of dynamic-covalent crosslinking interactions between phenylboronic acids and diols.

Stimuli-responsive polypeptide tags direct the assembly of active proteins into supramolecular assemblies. This allows for recombinant expression of soluble fusion protein and subsequent user-controlled formation of functional biomaterials.

Nanoparticles of photoresponsive liquid–liquid phase-separation polymers complexed with liquid metals can concentrate drugs upon photoirradiation, opening up new DDS horizons.

An artificial disulfide bond was rationally constructed in human cytochrome c (hCyt c) via double mutations (A51C/G77C), which weakened the coordination of Met80 to the heme iron and enhanced the peroxidase activity of hCyt c.

E. coli was used to produce chondroitin both in silico and in vivo, marking the first use of genome-scale metabolic models to predict its production. Identified targets can guide future works towards more efficient hosts for chondroitin production.

The development of structurally controlled techniques inspired by the structural formation of living systems is of great importance for the fabrication of next-generation functional soft materials using environmentally friendly processes.

By drawing on similarities between energy landscapes and model response surfaces we gain new insight into model performance, even in the absence of data.

Melanin-like nanoparticles decorated with gold nanoparticles are presented as cancer-targeting near-infrared (NIR) photothermal agents with excellent photothermal conversion and stability.

A model was developed to help predict how enzymes can be used to temporally control the gelation of polyvinyl alcohol (PVA) with borate.

Light-activated molecular motors rotate at a similar frequency in polymersomes and in solution.

PqsD is an anthraniloyl-CoA anthraniloyltransferase involved in the synthesis of the secondary metabolites essential to the formation of Pseudomonas quinolone signal (PQS) inducer molecules.