Issue 34, 2010
From the journal:

Chemical Communications

Structural insights into substrate specificity and solvent tolerance in alcohol dehydrogenaseADH-‘A’ from Rhodococcus ruberDSM 44541†‡

Martin Karabec,a   Andrzej Łyskowski,a   Katharina C. Tauber,b   Georg Steinkellner,c   Wolfgang Kroutil,b   Gideon Grogan*d  and  Karl Gruber*a  

* Corresponding authors

a Institute of Molecular Biosciences, University of Graz, Humboldtstrasse 50/3, A-8010 Graz, Austria
E-mail: karl.gruber@uni-graz.at
Fax: +43 316 380 9897
Tel: +43 316 380 5483

b Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, Heinrichstrasse 28, 8010 Graz, Austria

c Austrian Centre of Industrial Biotechnology, Petersgasse 14, A-8010 Graz, Austria

d York Structural Biology Laboratory, Department of Chemistry, University of York, YO10 5YW York, UK
E-mail: grogan@ysbl.york.ac.uk
Fax: +44 (0)1904 328266
Tel: +44 (0)1904 328256

Abstract

The structure of the alcohol dehydrogenase ADH-‘A’ from Rhodococcus ruber reveals possible reasons for its remarkable tolerance to organic co-solvents and suggests new directions for structure-informed mutagenesis to produce enzymes of altered substrate specificity or improved selectivity.

Graphical abstract: Structural insights into substrate specificity and solvent tolerance in alcohol dehydrogenase ADH-‘A’ from Rhodococcus ruber DSM 44541

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Article information

DOI
https://doi.org/10.1039/C0CC00929F
Article type
Communication
Submitted
14 apr 2010
Accepted
09 jul 2010
First published
02 aug 2010

Chem. Commun., 2010,46, 6314-6316

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Structural insights into substrate specificity and solvent tolerance in alcohol dehydrogenase ADH-‘A’ from Rhodococcus ruber DSM 44541

M. Karabec, A. Łyskowski, K. C. Tauber, G. Steinkellner, W. Kroutil, G. Grogan and K. Gruber, Chem. Commun., 2010, 46, 6314 DOI: 10.1039/C0CC00929F

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