Issue 43, 2010
From the journal:

Chemical Communications

Phage display selection of miniprotein binders of the Estrogen Receptor†‡

Trang Phan,§a   Hoang D. Nguyen,§a   Hülya Göksel,a   Sabine Möcklinghoffab  and  Luc Brunsveld*ab  

* Corresponding authors

a Chemical Genomics Centre of the Max Planck Society, Otto-Hahn Strasse 15, Dortmund, Germany

b Laboratory of Chemical Biology, Department of Biomedical Engineering, Technische Universiteit Eindhoven, Den Dolech 2, Eindhoven, the Netherlands
E-mail: l.brunsveld@tue.nl
Fax: +31 40 2478367
Tel: +31 40 2473737

Abstract

Miniprotein phage display screening yields structured peptides with high affinity for the Estrogen Receptor (ER). Hits from apamin phage libraries feature a LXXLL motif specifically placed on the predefined miniprotein helical segment. The apamin scaffold also allows optimization of flanking amino acids to ensure an optimal ER binding affinity.

Graphical abstract: Phage display selection of miniprotein binders of the Estrogen Receptor

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Article information

DOI
https://doi.org/10.1039/C0CC02727H
Article type
Communication
Submitted
22 jul 2010
Accepted
10 sep 2010
First published
27 sep 2010

Chem. Commun., 2010,46, 8207-8209

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Phage display selection of miniprotein binders of the Estrogen Receptor

T. Phan, H. D. Nguyen, H. Göksel, S. Möcklinghoff and L. Brunsveld, Chem. Commun., 2010, 46, 8207 DOI: 10.1039/C0CC02727H

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