Hemant Sharma, Nian Kee Tan, Natalie Trinh, Jia Hao Yeo, Elizabeth J. New and Frederick M. Pfeffer
Chem. Commun., 2020,56, 2240-2243
DOI:
10.1039/C9CC09748A,
Communication
A fluorescent, naphthalimide-based, NADH mimic has been synthesised as a reversible, biocompatible, “on–off” probe for the detection of changes in intracellular redox environment (both oxidation and reduction). Interconversion was confirmed by means of electrochemistry and also 1H NMR, UV-vis and fluorescence spectroscopy. The reversibility was also successfully detected in A549 cells under simulated redox stress.
