Issue 17, 2010
From the journal:

Chemical Communications

An unnatural amino acid that mimics phosphotyrosine†

Jingyan Ge,a   Hao Wub  and  Shao Q. Yao*abc  

* Corresponding authors

a Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543

b Department of Biological Sciences, National University of Singapore, 3 Science Drive 3, Singapore 117543

c NUS MedChem Program of the Life Sciences Institute, National University of Singapore, 3 Science Drive 3, Singapore 117543
E-mail: chmyaosq@nus.edu.sg
Fax: (+65) 67791691
Tel: (+65) 65162925

Abstract

By replacing the phosphate group in pTyr with an isoxazole carboxylic acid, a novel unnatural amino acid has been successfully synthesized. Subsequently, its incorporation into a known PPI (protein–protein interaction) inhibitor of STAT3 protein (ISS 610) generated I2 which showed reasonable anti-STAT3 activity in both fluorescence polarization and cell-proliferation experiments.

Graphical abstract: An unnatural amino acid that mimics phosphotyrosine

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C000283F
Article type
Communication
Submitted
06 jan 2010
Accepted
13 feb 2010
First published
05 mrt 2010

Chem. Commun., 2010,46, 2980-2982

Permissions

Request permissions

An unnatural amino acid that mimics phosphotyrosine

J. Ge, H. Wu and S. Q. Yao, Chem. Commun., 2010, 46, 2980 DOI: 10.1039/C000283F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements