Fluorinase mediated chemoenzymatic synthesis of [18F]-fluoroacetate

Xiang-Guo Li; Juozas Domarkas; David O'Hagan

doi:10.1039/C0CC02264K

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Fluorinase mediated chemoenzymatic synthesis of [¹⁸F]-fluoroacetate†‡

Xiang-Guo Li,*^ab Juozas Domarkas^c and David O'Hagan*^a

Author affiliations

* Corresponding authors

^a University of St Andrews, School of Chemistry and Centre for Biomolecular Sciences, North Haugh, St Andrews, Fife, UK
E-mail: do1@st-andrews.ac.uk
Fax: +44 (0)1334 463800
Tel: +44 (0)1334 467171

^b Department of Pharmacology, Drug Development and Therapeutics/Laboratory of Synthetic Drug Chemistry, Institute of Biomedicine, University of Turku, Lemminkaisenkatu 5C, 20520 Turku, Finland
E-mail: xiali@utu.fi

^c John Mallard Scottish PET Centre, School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK

Abstract

A novel preparation of sodium [¹⁸F]-fluoroacetate is described where 5′-[¹⁸F]-fluoro-5′-deoxyadenosine is generated by a fluorinase catalysed reaction of S-adenosyl-L-methionine (SAM) with no carrier added [¹⁸F]-fluoride and then oxidation to [¹⁸F]-fluoroacetate by a Kuhn–Roth oxidative degradation.

This article is part of the themed collection: Enzymes and Proteins

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Supplementary files

Fluorinase production, Kuhn–Roth oxidation and methods for [ ¹⁸F]-fluoroacetate synthesis in detail PDF (349K)

Article information

DOI: https://doi.org/10.1039/C0CC02264K
Article type: Communication
Submitted: 30 jun 2010
Accepted: 17 aug 2010
First published: 20 sep 2010

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Chem. Commun., 2010,46, 7819-7821

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Fluorinase mediated chemoenzymatic synthesis of [¹⁸F]-fluoroacetate

X. Li, J. Domarkas and D. O'Hagan, Chem. Commun., 2010, 46, 7819 DOI: 10.1039/C0CC02264K

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