Issue 25, 2015

Photostable AIE fluorogens for accurate and sensitive detection of S-phase DNA synthesis and cell proliferation

Abstract

Two azide-functionalized tetraphenylethene derivatives with AIE features are synthesized and used as fluorescent agents for detecting S-phase DNA synthesis and cell proliferation based on EdU assay. Compared to the Alexa-azide dye, a commercial DNA bioprobe, the AIE fluorogens show better photostability and sensitivity, making them promising alternatives.

Graphical abstract: Photostable AIE fluorogens for accurate and sensitive detection of S-phase DNA synthesis and cell proliferation

Supplementary files

Article information

Article type
Communication
Submitted
12 mrt 2015
Accepted
14 apr 2015
First published
14 apr 2015

J. Mater. Chem. B, 2015,3, 4993-4996

Author version available

Photostable AIE fluorogens for accurate and sensitive detection of S-phase DNA synthesis and cell proliferation

Y. Zhao, C. Y. Y. Yu, R. T. K. Kwok, Y. Chen, S. Chen, J. W. Y. Lam and B. Z. Tang, J. Mater. Chem. B, 2015, 3, 4993 DOI: 10.1039/C5TB00458F

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