Issue 1, 2016
From the journal:

Chemical Science

Next-generation disulfide stapling: reduction and functional re-bridging all in one†

Maximillian T. W. Lee,a   Antoine Maruani,a   James R. Baker,a   Stephen Caddicka  and  Vijay Chudasama ORCID logo *a  

* Corresponding authors

a Department of Chemistry, University College London, 20 Gordon Street, London, United Kingdom
E-mail: v.chudasama@ucl.ac.uk
Tel: +44207 679 2077

Abstract

Herein we present a significant step towards next-generation disulfide stapling reagents. A novel class of reagent has been designed to effect both disulfide reduction and functional re-bridging. The strategy has been applied to great success across various peptides and proteins. Moreover, application to a multi-disulfide system resulted in functional re-bridging without disulfide scrambling.

Graphical abstract: Next-generation disulfide stapling: reduction and functional re-bridging all in one

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Article information

DOI
https://doi.org/10.1039/C5SC02666K
Article type
Edge Article
Submitted
22 jul 2015
Accepted
13 sep 2015
First published
15 sep 2015
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2016,7, 799-802

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Next-generation disulfide stapling: reduction and functional re-bridging all in one

M. T. W. Lee, A. Maruani, J. R. Baker, S. Caddick and V. Chudasama, Chem. Sci., 2016, 7, 799 DOI: 10.1039/C5SC02666K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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