Structure elucidation and quantification of the reduction products of anticancer Pt(IV) prodrugs by electrochemistry/mass spectrometry (EC-MS)

L. M. Frensemeier; J. Mayr; G. Koellensperger; B. K. Keppler; C. R. Kowol; U. Karst

doi:10.1039/C8AN00258D

Structure elucidation and quantification of the reduction products of anticancer Pt(iv) prodrugs by electrochemistry/mass spectrometry (EC-MS)†

L. M. Frensemeier,^a J. Mayr,^b G. Koellensperger,^c B. K. Keppler,^b C. R. Kowol

*^b and U. Karst

*^a

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* Corresponding authors

^a Institute of Inorganic and Analytical Chemistry, University of Münster, Corrensstr. 28/30, 48149 Münster, Germany
E-mail: christian.kowol@univie.ac.at, uk@uni-muenster.de

^b Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Währinger Str. 42, 1090 Vienna, Austria

^c Institute of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Währinger Str. 38, 1090 Vienna, Austria

Abstract

Pt(IV) prodrugs are a class of promising anticancer agents, which are activated by reduction to the active Pt(II) species. Consequently, the reduction process is a crucial parameter. Herein, a new approach using electrochemistry (EC) coupled to liquid chromatography (LC) and electrospray ionization-mass spectrometry (ESI-MS) or inductively coupled plasma (ICP)-MS was applied. This enabled getting insights into the differences in the reduction and ligand release of platinum(IV) complexes with varying equatorial core structures.

This article is part of the themed collection: Analyst Recent Open Access Articles

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DOI: https://doi.org/10.1039/C8AN00258D
Article type: Communication
Submitted: 09 feb 2018
Accepted: 29 mrt 2018
First published: 09 apr 2018
This article is Open Access

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Analyst, 2018,143, 1997-2001

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Structure elucidation and quantification of the reduction products of anticancer Pt(IV) prodrugs by electrochemistry/mass spectrometry (EC-MS)

L. M. Frensemeier, J. Mayr, G. Koellensperger, B. K. Keppler, C. R. Kowol and U. Karst, Analyst, 2018, 143, 1997 DOI: 10.1039/C8AN00258D

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Structure elucidation and quantification of the reduction products of anticancer Pt(iv) prodrugs by electrochemistry/mass spectrometry (EC-MS)†

Abstract

Supplementary files

Article information

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Structure elucidation and quantification of the reduction products of anticancer Pt(IV) prodrugs by electrochemistry/mass spectrometry (EC-MS)

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