Gold redox catalysis for cyclization/arylation of allylic oximes: synthesis of isoxazoline derivatives

Abstract

Base-assisted diazonium activation has been employed to promote gold(I)/(III) redox catalysis toward allylic oxime cyclization/aryl coupling. Functional isoxazolines were prepared with good to excellent yields, while the alternative photoactivation method provided trace amounts of the isoxazoline products. This study further broadens the scope of gold redox chemistry.