A three-dimensional DNA walker amplified FRET sensor for detection of telomerase activity based on the MnO2 nanosheet-upconversion nanoparticle sensing platform

Mingdi Xu; Junyang Zhuang; Xiaoyu Jiang; Xinzhong Liu; Dianping Tang

doi:10.1039/C9CC05387E

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A three-dimensional DNA walker amplified FRET sensor for detection of telomerase activity based on the MnO₂ nanosheet-upconversion nanoparticle sensing platform†

Mingdi Xu,

^a Junyang Zhuang,

*^b Xiaoyu Jiang,^a Xinzhong Liu^a and Dianping Tang

*^c

Author affiliations

* Corresponding authors

^a College of Ecological Environment and Urban Construction, Fujian University of Technology, Fuzhou 350108, P. R. China

^b Department of Pharmaceutical Analysis, The Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, School of Pharmacy, Fujian Medical University, Fuzhou 350122, China
E-mail: Junyang.Zhuang@hotmail.com

^c Key Laboratory of Analysis and Detection for Food Safety (Ministry of Education & Fujian Province), Institute of Nanomedicine and Nanobiosensing, Department of Chemistry, Fuzhou University, Fuzhou 350108, P. R. China
E-mail: dianping.tang@fzu.edu.cn

Abstract

A novel fluorescent sensing platform for telomerase activity assay was developed by coupling a three-dimensional (3D) DNA walker with the MnO₂ nanosheet-upconversion nanoparticle (UCNPs) complex-based fluorescence resonance energy-transfer (FRET) system.

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Article information

DOI: https://doi.org/10.1039/C9CC05387E
Article type: Communication
Submitted: 13 jul 2019
Accepted: 23 jul 2019
First published: 26 jul 2019

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Chem. Commun., 2019,55, 9857-9860

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A three-dimensional DNA walker amplified FRET sensor for detection of telomerase activity based on the MnO₂ nanosheet-upconversion nanoparticle sensing platform

M. Xu, J. Zhuang, X. Jiang, X. Liu and D. Tang, Chem. Commun., 2019, 55, 9857 DOI: 10.1039/C9CC05387E

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