Nanoscopic insights into the surface conformation of neurotoxic amyloid β oligomers

Martina Banchelli; Roberta Cascella; Cristiano D'Andrea; Leszek Cabaj; Iacopo Osticioli; Daniele Ciofini; Mai Suan Li; Krzysztof Skupień; Marella de Angelis; Salvatore Siano; Cristina Cecchi; Roberto Pini; Giovanni La Penna; Fabrizio Chiti; Paolo Matteini

doi:10.1039/D0RA03799K

Nanoscopic insights into the surface conformation of neurotoxic amyloid β oligomers†

Martina Banchelli,^a Roberta Cascella,

^b Cristiano D'Andrea,

^a Leszek Cabaj,^c Iacopo Osticioli,^a Daniele Ciofini,^a Mai Suan Li,

^de Krzysztof Skupień,^c Marella de Angelis,^a Salvatore Siano,^a Cristina Cecchi,

^b Roberto Pini,^a Giovanni La Penna,

^f Fabrizio Chiti

*^b and Paolo Matteini

*^a

Author affiliations

* Corresponding authors

^a Institute of Applied Physics “Nello Carrara”, National Research Council, Via Madonna Del Piano 10, I-50019 Sesto Fiorentino, Italy
E-mail: p.matteini@ifac.cnr.it

^b Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, I-50134 Firenze, Italy
E-mail: fabrizio.chiti@unifi.it

^c 3D-Nano, 30-702 Kraków, Poland

^d Institute of Physics, Polish Academy of Sciences, Al.Lotnikow 32/46, 02-668 Warsaw, Poland

^e Institute for Computational Science and Technology, SBI Building, Quang Trung Software City, Tan Chanh Hiep Ward, District 12, Ho Chi Minh City, Vietnam

^f Institute of Chemistry of Organometallic Compounds, National Research Council, Via Madonna Del Piano 10, I-50019 Sesto Fiorentino, Italy

Abstract

Raman spectroscopy assisted by localized plasmon resonances generating effective hot spots at the gaps between intertwined silver nanowires is herein adopted to unravel characteristic molecular motifs on the surface of Aβ₄₂ misfolded oligomers that are critical in driving intermolecular interactions in neurodegeneration.

This article is part of the themed collection: Nanomaterial applications

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Nanoscopic insights into the surface conformation of neurotoxic amyloid β oligomers†

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