A novel phage display based platform for exosome diversity characterization

Domenico Maisano; Selena Mimmi; Vincenzo Dattilo; Fabiola Marino; Massimo Gentile; Eleonora Vecchio; Giuseppe Fiume; Nancy Nisticò; Annamaria Aloisio; Maria Penelope de Santo; Giovanni Desiderio; Vincenzo Musolino; Saverio Nucera; Francesca Sbrana; Sebastiano Andò; Simone Ferrero; Andrea Morandi; Francesco Bertoni; Ileana Quinto; Enrico Iaccino

doi:10.1039/D1NR06804K

A novel phage display based platform for exosome diversity characterization†

Domenico Maisano,

‡^a Selena Mimmi,‡^a Vincenzo Dattilo,^b Fabiola Marino,^a Massimo Gentile,^c Eleonora Vecchio,^a Giuseppe Fiume,^a Nancy Nisticò,^a Annamaria Aloisio,^a Maria Penelope de Santo,^d Giovanni Desiderio,^d Vincenzo Musolino,^e Saverio Nucera,^e Francesca Sbrana,^f Sebastiano Andò,*^g Simone Ferrero,^h Andrea Morandi,ⁱ Francesco Bertoni,

^j Ileana Quinto §^a and Enrico Iaccino §*^a

Author affiliations

* Corresponding authors

^a Department of Experimental and Clinical Medicine, University “Magna Graecia of Catanzaro”, Catanzaro, Italy
E-mail: iaccino@unicz.it

^b Genetics Units, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy

^c Hematology Unit, Annunziata Hospital, Cosenza, Italy

^d CNR/Nanotec, Physics Department, University of Calabria, Rende, CS, Italy

^e IRC-FSH Department of Health Sciences, University “Magna Græcia” of Catanzaro, Catanzaro, Italy

^f Schaefer SEE srl, Via Luigi Einaudi 23, Rovigo, RO, Italy

^g Health Center, University of Calabria, Rende, CS, Italy
E-mail: sebastiano.ando@unical.it

^h Division of Hematology, Department of Molecular Biotechnologies and Health Sciences, University of Torino, Turin, Italy

ⁱ Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy

^j IOR, Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona, Switzerland

Abstract

We present an innovative approach allowing the identification, isolation, and molecular characterization of disease-related exosomes based on their different antigenic reactivities. The designed strategy could be immediately translated into any disease in which exosomes are involved. The identification of specific markers and their subsequent association with exosome subtypes, together with the possibility to engineer target-guided exosome-like particles, could represent the key for the effective adoption of exosomes in clinical practice.

This article is part of the themed collection: Nanoscale and Nanoscale Horizons: Nanobiotechnology and Nanomedicine

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A novel phage display based platform for exosome diversity characterization†

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A novel phage display based platform for exosome diversity characterization

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