Issue 21, 2011

Modular ‘click’ sensors for zinc and their application in vivo

Abstract

Although the central role that zinc plays in many biological processes and important disease states is now well-established, there remains a pressing need to develop an absolute understanding of the underlying biology of zinc trafficking in terms of its dynamic and quantitative processing in specific organelles. Here we describe the modular synthesis of zinc sensors using a ‘click’ approach and demonstrate the applicability of our new sensors in vivo using a zebrafish model.

Graphical abstract: Modular ‘click’ sensors for zinc and their application in vivo

Supplementary files

Article information

Article type
Communication
Submitted
28 feb 2011
Accepted
31 mrt 2011
First published
28 apr 2011

Chem. Commun., 2011,47, 6036-6038

Modular ‘click’ sensors for zinc and their application in vivo

K. Jobe, C. H. Brennan, M. Motevalli, S. M. Goldup and M. Watkinson, Chem. Commun., 2011, 47, 6036 DOI: 10.1039/C1CC11213A

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