Issue 26, 2019
From the journal:

Chemical Communications

Palladium-catalysed ligand-free reductive Heck cycloisomerisation of 1,6-en-α-chloro-enamides†

Yangyang Hou,‡a   Jing Ma,‡a   Hongyi Yang,a   Edward A. Anderson, ORCID logo b   Andy Whiting ORCID logo c  and  Na Wu ORCID logo *ac  

* Corresponding authors

a State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Gulin, Guangxi, China
E-mail: wuna07@gxnu.edu.cn

b Chemistry Research Laboratory, Oxford University, 12 Mansfield Road, Oxford, UK

c Department of Chemistry, Durham University, South Road, Durham DH1 3LE, UK
E-mail: na.wu@durham.ac.uk

Abstract

The first example of an intramolecular hydroarylation of 1,6-en-α-chloro-enamides was achieved by a palladium-catalysed ligand-free reductive Heck cycloisomerisation with no competing Heck-cyclised by-product.

Graphical abstract: Palladium-catalysed ligand-free reductive Heck cycloisomerisation of 1,6-en-α-chloro-enamides

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Article information

DOI
https://doi.org/10.1039/C9CC00537D
Article type
Communication
Submitted
21 jan 2019
Accepted
04 mrt 2019
First published
04 mrt 2019

Chem. Commun., 2019,55, 3733-3736

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Palladium-catalysed ligand-free reductive Heck cycloisomerisation of 1,6-en-α-chloro-enamides

Y. Hou, J. Ma, H. Yang, E. A. Anderson, A. Whiting and N. Wu, Chem. Commun., 2019, 55, 3733 DOI: 10.1039/C9CC00537D

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