Analytical science in neurochemistry
Jean-François Masson, Parastoo Hashemi and Martyn Boutelle introduce the Analyst themed collection on Analytical Science in Neurochemistry.
Raman spectroscopy and neuroscience: from fundamental understanding to disease diagnostics and imaging
In recent years, Raman spectroscopy-based methods have contributed significantly to the understanding of neurological structure, function, and disease.
Imaging mass spectrometry allows for neuroanatomic-specific detection of gangliosides in the healthy and diseased brain
Gangliosides have a wide variety of biological functions due to their location on the outer leaflet of plasma membranes.
Fundamentals of fast-scan cyclic voltammetry for dopamine detection
Fast-scan cyclic voltammetry (FSCV) is used with carbon-fiber microelectrodes for the real-time detection of neurotransmitters on the subsecond time scale.
Gadolinium-based MRI contrast agent for the detection of tyrosinase
We successfully designed and synthesized a tyrosinase-targeting Gd(III)-based MR contrast agent. The probe shows enhanced T1 relaxation rate in the presence of tyrosinase in artificial cerebral spinal fluid.
The analysis of single cysteine molecules with an aerolysin nanopore
Biological nanopore technology has the advantages of high selectivity and high reproducibility for characterizing single biomolecules.
Electrochemical detection of exogenously administered melatonin in the brain
Optimized square wave voltammetry for electrochemical measurement of exogenously administered MT in vivo.
Electroenzymatic glutamate sensing at near the theoretical performance limit
Optimized sensors will enable more accurate monitoring of glutamate signaling in vivo.
Real-time neurochemical measurement of dynamic metabolic events during cardiac arrest and resuscitation in a porcine model
This work describes a fully-integrated portable microfluidic analysis system for real-time monitoring of dynamic changes in glucose and lactate occurring in the brain as a result of cardiac arrest and resuscitation.
Surface-enhanced spatially-offset Raman spectroscopy (SESORS) for detection of neurochemicals through the skull at physiologically relevant concentrations
Detection techniques for neurotransmitters that are rapid, label-free, and non-invasive are needed to move towards earlier diagnosis of neurological disease.
Progress toward the development of a microchip electrophoresis separation-based sensor with electrochemical detection for on-line in vivo monitoring of catecholamines
Development of an easily fabricated MD–ME–EC set up for continuous on-line in vivo monitoring of neuroactive compounds in rat brain including dopamine.
Plasma-treated carbon-fiber microelectrodes for improved purine detection with fast-scan cyclic voltammetry
New carbon surfaces for significantly improved detection of purine analytes with fast-scan cyclic voltammetry.
A target-driven DNA-based molecular machine for rapid and homogeneous detection of arginine-vasopressin
A DNA-based molecular machine triggered only by a specific target neuropeptide has been developed and integrated with fluorescence signal amplification system. It enabled rapid and sensitive detection of the target neuropeptide in biological matrices.
A method for recording the two phases of dopamine release in mammalian brain striatum slices
Striatal dopamine (DA) release plays an essential role in many physiological functions including motor and non-motor behaviors (such as reward, motivation, and cognition).
Capillary electrophoresis coupled to MALDI mass spectrometry imaging with large volume sample stacking injection for improved coverage of C. borealis neuropeptidome
This work reports on a capillary electrophoresis (CE) separation method coupled to matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) imaging for improved neuropeptide coverage in the model organism Cancer borealis.
A cobalt corrole/carbon nanotube enables simultaneous electrochemical monitoring of oxygen and ascorbic acid in the rat brain
Simultaneous detection of O2 and ascorbic acid in the rat brain using a cobalt corrole and carbon nanotube nanocomposite modified carbon fiber electrode.
Developing infrared spectroscopic detection for stratifying brain tumour patients: glioblastoma multiforme vs. lymphoma
There are currently no methods in place for the early detection of brain cancer. A reliable serum triage test could avoid the need for surgery, and speed up time to definitive treatment. Could high-throughput infrared spectroscopy fill the void?
Determination of tryptophan metabolism from biological tissues and fluids using high performance liquid chromatography with simultaneous dual electrochemical detection
Our study develops a methodology for monitoring of analytes from the kynurenine and serotonin pathway following tryptophan metabolism.
About this collection
A collection of reviews and research papers focusing on the latest advances in analytical science for neurochemistry. Better understanding neurochemistry of the brain is necessary for improving treatments of neurological and psychiatric diseases. Analytical sciences plays an important role in this field, with the design of novel instrumental tools to detect neurotransmitters and other biologically-active molecules in the brain. Recent efforts in electrochemical sensing, micro-separation sciences, mass spectrometry, and spectroscopic techniques further advances our capacity to measure molecules in the brain.
This collection is Guest Edited by Analyst Associate Editor Jean-François Masson (University of Montreal, Canada), Parastoo Hashemi (University of South Carolina, USA) and Martyn Boutelle (Imperial College London, UK).