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The synthesis of a water soluble [2]rotaxane is reported using hydrophilic secondary rim functionalised permethylated β-cyclodextrin derivatives as the axle stopper groups. The rotaxane recognises halide anions in pure water with impressive selectivity over sulfate.

Graphical abstract: Anion recognition in water by a rotaxane containing a secondary rim functionalised cyclodextrin stoppered axle

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