The quantum-confined superfluid (QSF) concept has been proposed for ultrafast mass transport, which is mainly related to the orderly flow of fluid in a nanoconfined space. Besides biological ionic channels, artificial nanochannels have also demonstrated the QSF phenomenon. Here, the authors’ insight into QSF is introduced, followed by exploring the extended applications to diverse fields, such as QSF-based chemistry and QSF-based biology. For chemistry, the orderly arranged molecules in nanoconfined space will greatly reduce the reaction barrier and achieve highly efficient and selective chemical synthesis. Additionally, the QSF-based biology is of great significance for the deep understanding of ultrafast signal transmission in the nerves and brain, with implications for information systems and medical sciences.