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Towards a dynamic covalent molecular switch: substituent effects in chalcone/flavanone isomerism
Jesse Mai, Ermal Hoxha, Caitlin E. Morton, Brian M. Muller and Marc J. Adler Org. Biomol. Chem., 2013,11, 3421-3423
DOI:
10.1039/C3OB40467F,
Communication
Chalcone/flavanone interconversion occurs facilely under aqueous alkaline conditions making it a promising scaffold for the development of a covalent molecular switch. In this study, a single methoxy substituent is shown to have a significant impact on the equilibrium dynamics of this reaction; this impact is dependent on the site of substitution.